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Novarum Scholar — Research Digest
New papers in CRISPR gene editing
Tuesday, April 21, 2026  ·  3 new articles
Nature Biotechnology· Apr 19, 2026
High-fidelity prime editing in human hematopoietic stem cells
Researchers demonstrate a refined prime editing approach achieving over 90% efficiency in HSCs with minimal off-target effects, advancing CRISPR-based therapies for sickle cell disease and beta-thalassemia.
Read paper
bioRxiv· Apr 20, 2026PREPRINT
Compact Cas9 variants enable efficient in vivo delivery via AAV vectors
A new family of miniaturized Cas9 nucleases fits within AAV packaging limits while maintaining editing efficacy, overcoming a major barrier for in vivo therapeutic delivery.
Read paper
+ 1 more article in this issue

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